| ncRNA name | hsa-miR-26a |
| ncRNA Category | miRNA |
| Disease name | cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | human lens epithelial cell line SRA01/04 |
| Methods | microarray, qPCR, Western blot, immunofluorescence staining, luciferase reporter assay |
| Expression pattern | down-regulated |
| Functional description | Using gain- and loss-of-function assays, and different lens fibrosis models, here we demonstrated that microRNA (miR)-26a and miR-26b, members of the miR-26 family have key roles in EMT and fibrosis. They can significantly inhibit proliferation, migration, EMT of lens epithelial cells and lens fibrosis in vitro and in vivo. |
| PubMed ID | 28622289 |
| Year | 2017 |
| Title | MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway. |
| Drug-related ncRNA | NO |
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